A community-wide data processing challenge for cryo-electron microscopy.
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Sign up for email notifications for challenge announcements here.
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Join the challenge discussions space on GitHub here.
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Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling high-resolution visualization of heterogeneous biomolecular assemblies. However, a central challenge remains: developing computational methods that can resolve structural heterogeneity including continuous motions, discrete states, and compositional heterogeneity.
To encourage the development and benchmarking of HRAs, we invite the cryo-EM community to test single particle reconstruction algorithms on three new curated synthetic and experimental datasets:
If you are interested in participating, please sign up for email notifications and join our discussions space. Please share this challenge with others who may be interested. We hope you’ll join us for this year’s competition!
| Datasets released, submissions open | October, 2025 |
|---|---|
| Webinar | October, 2025 |
| Submissions close | June, 2026 |
| Results announced | Summer 2026 |
| CCP-EM challenge workshop | September 2026 |
This page will be updated with more information when the datasets are released.
Join the challenge discussions space on GitHub.